Bloom, Iggy and Reynolds rally around Max as he deals with the fallout from Helen’s decision. Bloom gives extra space to Leyla, but she’s in for a surprise. Reynolds and Wilder help a young terminal patient realize his dream to star in a Bollywood show. Iggy has a breakthrough with a challenging patient.

Max tests a bold new cost-saving program that could help both New Amsterdam and its neediest patients. Wilder struggles with a patient’s decision to refuse life-saving surgery. Reynolds comes to an important realization about his father’s behaviors. Iggy takes the leap into online dating.

An explosion at a wedding ceremony sends a stream of injured partygoers into New Amsterdam. While Max and Dr. Wilder scramble to find a rare blood type to save the groom, Reynolds and Bloom treat a couple with bizarre injuries. While helping a young girl out of a catatonic state, Iggy learns the truth about the wedding.

Max goes on a mission to make New York safer. Iggy helps a family come to terms with their deaf child’s inability to communicate.

Max discovers a revenue-generating department at the hospital that has serious legal implications. Iggy discovers a janitor with otherworldly talents. Reynolds treats a truly inspirational patient and makes plans for his father. Wilder's young patient teaches her not to jump to conclusions in diagnosing.

Reynolds gets creative to help a prospective mother in need. Max takes a chance with Wilder and learns a hard truth. Bloom treats a young brother and sister in dire straits. Iggy reaches a decision about Martin.

Reynolds finds himself caught between a chance for love and an opportunity to spend precious time with his father. Realizing the consequences of her actions, Bloom makes an unexpected move forward with her sister. Max helps an ICU intern struggling with the loss of a patient. Dr. Wilder receives an offer that forces her to choose between her community and her career.