Max and Sharpe go public with their relationship at the hospital. The team struggles to handle an overcrowded and understaffed ICU. Iggy's overly critical feedback alienates his residents.

Max takes drastic measures to help several undocumented immigrants after a fire destroys the church where had sought refuge; Sharpe and Malvo assist a patient with a life threatening condition; Reynolds is conflicted about his new position.

As Max and Dr. Sharpe prepare to depart for London, a deadly superbug hits the hospital and draws them back in. Leyla confronts Bloom about the secret she has been hiding. Iggy digs deep to help two grieving parents confront the reality that their son is gone.

Max and Helen adjust to sharing their lives and problems, including the challenge of Helen's mother. Bloom and Reynolds treat a family after their horrific car accident lands them in the ED. Iggy and Trevor reach a new understanding in their business relationship.

The New Amsterdam team continues to deal with the consequences of their big night out. Max and Helen discuss options for their future. Martin finally learns Iggy's secret. Bloom helps Leyla avoid a life-changing situation. Reynolds and Dr. Malvo define their relationship going forward.

As a monster hurricane approaches New York, Bloom and the team scramble to put preparations in place. Max and Helen make plans for an intimate New York wedding as she returns from London. Iggy and Martin reach a crossroads. Reynolds finally makes contact with his father.

Bloom, Iggy and Reynolds rally around Max as he deals with the fallout from Helen’s decision. Bloom gives extra space to Leyla, but she’s in for a surprise. Reynolds and Wilder help a young terminal patient realize his dream to star in a Bollywood show. Iggy has a breakthrough with a challenging patient.

Max mandates a personal health day for the staff at New Amsterdam and meets with surprising resistance. Reynolds finds himself intrigued by a persuasive new member of the staff. Bloom struggles with job stress after being taken off an essential medication. Iggy goes on his first date. Max convinces Wilder to get much needed surgery.

Max goes on a mission to make New York safer. Iggy helps a family come to terms with their deaf child’s inability to communicate.