Dr. Max Goodwin shakes up the status quo on his first day as medical director of New Amsterdam, the oldest public hospital in the United States, while simultaneously dealing with his own personal and health issues.

A visiting journalist picks at the hospital's flaws while shadowing Max; Bloom and Reynolds have a major disagreement after Bloom makes a call against protocol; Kapoor confronts issues from his past.

With a big domino transplant procedure on the line, Max must decide if he can be present in the hospital while also dealing with his illness. Meanwhile, a bond with a patient makes Bloom consider her personal life and Iggy makes progress on a long-standing case.

As the doctors continue to weather the storm without power, Max relies on an unlikely source to get the lights back on. Reynolds must get creative as he continues to work to save Hugh with very few resources.

When a NYPD officer is hit by a car in the line of duty, the hospital is turn upside down trying to save her. Meanwhile, Kapoor and Iggy work with a patient struggling with a previous surgery.

Max invokes a hospital-wide census in effort to get to know the staff of New Amsterdam on a deeper level. Reynolds takes a leap of faith that lands him in hot water, and Dr. Castro extends her treatment plan to more patients in the hospital.

When Iggy and Kapoor discover a patient might be suffering from lead poisoning, they are forced to take on the city. Meanwhile, Max's unsolicited attempts to help a patient backfires.

A burst pipe plunges the ED into chaos. Iggy counsels two stressed out parents about their child. Gwen and Calvin have some devastating news for Max.

Max takes drastic measures to help several undocumented immigrants after a fire destroys the church where had sought refuge; Sharpe and Malvo assist a patient with a life threatening condition; Reynolds is conflicted about his new position.