Several thousand years after a mysterious phenomenon turns all of humanity to stone, the extraordinarily intelligent, science-driven boy, Senku Ishigami, awakens from petrification. Facing a world of stone and the total collapse of civilization, Senku makes up his mind to use science to rebuild the world. Starting with his super strong childhood friend Taiju Oki, who awakened at the same time, they will begin to rebuild civilization from nothing. Depicting two million years of scientific history from the Stone Age to present day, the unprecedented crafting adventure story is about to begin.

Facing immediate danger from wild animals Senku and Taiju are forced to revive Tsukasa Shishio "The Strongest High School Primate". Although Tsukasa has tremendous fighting ability and provides abundant food as their hunter, their new ally harbors an opposing view on restoring humanity.

Senku does not trust the motivation of Shishio, so he will try to hide his plans from a new and unforeseen enemy for his plan to revive civilization.

Senku has the idea of ​​creating gunpowder to have a way to balance the scale and have a chance to defeat Shishio. The production of gunpowder causes a fire. Shortly thereafter, Senku and the others discover smoke signals on the horizon. An accident? Hardly likely. Apparently there are other people in the stone world ...

Shishio is determined to end Senku's life if he does not promise at that moment that he will abandon his idea of ​​recovering civilization as it was before the incident.

Taiju and Yuzuriha figure out Senku's secret to reviving him. But now that he's back, they need to deal with Tsukasa.

Kohaku shows Senku to her village, but it's going to take some convincing before they let him in. In the meantime, he makes friends with a like-minded, promising "sorcerer."

Kohaku's sister, village priestess Ruri, is gravely ill. Senku, Chrome and Kohaku begin their quest to make antibiotics to save her life.

Senku starts a ramen stand in hopes of winning over support for his kingdom of science, but some people are too principled to take such a bribe. Mentalist Asagiri Gen is not one of them.

The development of glassworks, an important step for making sulfa drugs and for chemistry as a whole, turns out to have a surprising benefit for Suika.

To make antibiotics, Senku and his kingdom need to obtain sulfuric acid from a fountain of the stuff. The team goes prepared, but there's no guarantee that they'll make it back alive.

All that's needed to make antibiotics is alcohol. The best way to get some is to win the Grand Bout, which the Senku and his kingdom will also need to do in order to keep Magma away from Ruri and give her the drug.

After Magma's series of tricks to reach the final match, Chrome reveals a trick of his own! With a little extra help from Gen, Chrome just may be able to pull this one off!

After Senku's unlikely victory, quick marriage, and even hastier divorce, the kingdom of science is back to work to finally finish Ruri's medicine!

Ruri reveals the origin of the village's name and Senku learns of his father's fate!

Byakuya and the astronauts' story continues, and Senku's connection to Ishigami Village and the Hundred Tales is finally revealed.

Tsukasa's army is coming! Kinro struggles to hold the bridge against the deadly spearman Hyoga and his shock troops, but Senku and the villagers are ready with deadly new weapons of science!

Hyoga is disarmed, but the kingdom of science is still in danger - Ishigami village is in flames! And Tsukasa will soon know that Senku is still alive... How will the villagers fight off the coming invasion?

Work begins on creating the components for Senku's cell phone, but spinning gold wire is proving to be quite the task! Luckily, Chrome and Kaseki "invent" the water wheel and drastically improve the process!

With Chrome and Kaseki’s water wheel finished, Ishigami Village moves into the age of electricity! But with the primitive materials available to him, will Senku be able to create a filament that can withstand the intense heat of operating a vacuum tube?

Senku, Chrome, and Magma venture into a cave in search of Tungsten, but there's a suspicious accident that leaves Senku and Chrome trapped at the bottom of a pit! What is Magma up to?!

Senku and the rest of the village get to work on making the components for the cell phone. It's hard work but everyone is pumped!

After a successful test of their new cell phone, Senku learns of a mysterious tale about a bee named Speaker who can play the voices of the dead.