Season 1 of Big White Duel premiered on June 10, 2019.

Season 2 of Big White Duel premiered on June 22, 2022.

With CE Yeung Yat-to and Deputy CE Tong Ming at the helm of the leading public health institution Marshall Paxton Hospital, core departments, namely neurosurgery, CTS and A&E, are writing life-saving medical stories. The failed medical reform plan had not in any way frustrated Yat-to, who puts forward Comprehensive Opening Up of the Drug Formulary Bill with the aim of providing low-cost medications to rare disease patients. However, oncologist Ip Ching objects to his proposal, and she even goes against Yat-to as she is appointed as MarsPax CE. Meanwhile, former W.M.U. member Lee Man-shun joins the MarsPax team and collaborates with A&E Dr Zoe So, neurosurgeon Lui Oi-ling and other white knights in handling all kinds of critical situations.