Los Kent celebran el cumpleaños número 16 de los chicos y Lois recibe noticias sorprendentes.

Clark y Chrissy notan una pequeña grieta en la cara de juego de Lois; Sarah y Jordan tienen un encuentro incómodo; Lana recibe una llamada de pánico.

Lois y Chrissy buscan una nueva ventaja en la investigación de Mannheim contra los deseos de Clark. Mientras tanto, Jonathan, Jordan y Nat se enfrentan a un obstáculo inesperado.

Lois interrumpe una intensa conversación entre Clark y John Henry; Kyle intenta interponerse entre Sarah y Lana; Jonathan tiene una acalorada discusión con el padre de Candice.

Clark y el general Lane tienen dificultades para darle espacio a Lois para que tome sus propias decisiones; Lana y Sarah tienen un encuentro con un viejo amigo en el restaurante; Natalie tiene una visita sorpresa.

Clark finds himself in uncharted territory, and Lois bonds with a new friend. Meanwhile, Superman pays Bruno Mannheim a surprise visit.

Lois and Clark dig deeper on Bruno Mannheim, starting with his connections to Hob's Bay Medical Center, while Jonathan and Jordan panic at home over Lois' dire diagnosis.

After learning about Bruno and Peia, Clark works to reignite Lois' interest in taking Bruno down; elsewhere, Natalie meets Matteo's parents, with disastrous consequences.

Superman and John Henry clash over how to handle Bruno Mannheim, while Lois worries over upcoming treatments and confides in Lana about her early courtship with Clark.

Lois attempts to interview Peia in the hopes of unearthing the truth about an old case, while Clark struggles to spend quality time with the boys.

Clark helps Lois prepare for a procedure but must leave the boys with her to help John Henry and General Lane track down the Mannheims.

Finally, after seventeen years behind bars, Lex Luthor is set to be released from prison. Lois and Clark clash with Jordan over his carelessness around using his powers in public, while Jonathan struggles with Kyle's change in behavior at the firehouse.

All of Smallville comes together to view a meteor shower, and Lex Luthor makes his move to take down Superman and Lois.