Wolf is assigned to a patient that has lost hope that she will receive a life-saving lung transplant in time. Keon confides in a former football friend about a traumatic incident. Naz is assigned as Sinead's assistant.

Keon gets hazed by Nurse Molly, then gets off on the wrong foot with a patient in handcuffs. Wolf suddenly finds himself under serious financial pressure and considers taking desperate measures.

When Naz realizes her patient has a more serious condition than anyone realized, Naz forms a special bond with the patient's cousin. An over-exhausted and under-slept Wolf struggles on the job and draws Damien's wrath.

Ashley receives an ultra-religious patient who is willing to put himself at peril to appease God, forcing Ashley to reconsider her own religious past. Naz supports a pregnant patient through the hardest decision of her life.

A hospital is a battlefield, as our 5 favorite nurses attack another season. But there's a new general in town - nurse manager Kate Faulkner, who's going to give them all a run for their money.

An Amber Alert rings out at St. Mary's, but unbeknownst to the nurses the perpetrator and the abducted child are in the hospital.

Hospitals are no stranger to the things that keep us up at night or the secrets we keep, as the strange gets stranger on the night shift at St Mary's.

A high-profile surgical case brings Grace and Ashley into conflict over whether or not the surgeon is capable of performing the surgery.

Ghosts from the past make a day at St Mary's especially trying for our nurses as they're each confronted by people or things they tried to leave behind.

With uncertainty in their personal lives and a pandemic on the horizon, our nurses each deal with people longing for wishes to come true for their health or their loved ones, but they're wishes that may not be in the power of a nurse to grant.