Pinoy Big Brother: Teen Edition 1 began airing on April 23, 2006, three weeks after the end of the first Celebrity Edition. This is the third series overall in the franchise. It ran for 42 days and closely resembled the original show, unlike the relatively short Teen Big Brother, its British counterpart. The prizes included a condominium unit in Valenzuela City, a livelihood showcase, one million pesos, and an all-expense paid trip to any Philippine destination.

During the last few days of the above-mentioned first Celebrity Edition, auditions in Cebu City, Davao City, and Metro Manila were announced, and 30,000 teenagers answered the audition call. Of these, twelve housemates were selected: eight represented the Luzon area while four came from the Visayas and Mindanao.

Mariel Rodriguez took over as main host of the primetime edition, while former Celebrity Edition contestant Bianca Gonzalez hosted the UpLate edition of the show.

The theme song for this new edition was "Kabataang Pinoy" by Itchyworms. The new theme song was first performed by the band during the first Celebrity Edition's finale on April 1, 2006.

For this edition, the house was redecorated with a pop art theme. The colours of the walls were changed, and even the living area had a mural with pop art depictions of Mao Zedong, Bruce Lee, and Marilyn Monroe, to name a few. The housemates were also provided with a foosball table and some trampolines.