Professor Andrea Fanti, a brilliant Head of Internal Medicine, has his life turned upside down when the father of a patient who has died in his ward shoots him in the head. Andrea survives the shooting, but loses his memory of the last twelve years of his life. When he wakes up, he struggles to recognize his colleagues, his family and the man he had become.

Andrea is hospitalized in the Internal Medicine ward, in the hope that over time the place most familiar to him will help him recover his memory. Giulia oversees his rehabilitation, but finds herself dealing with a different man to the one she knew.

Andrea returns to the ward as an assistant to the trainees, who were terrified of him just a few weeks earlier and find it hard to get used to the unexpected role reversal. While he tries to win back his ex-wife, his collaboration with Giulia on the case of a young manager proves to be challenging and full of surprises.

The arrival of a patient who is particularly important to Giulia intensifies the competition between the interns and Andrea has an opportunity to really get to know them. Meanwhile, he involves the ward in the search for his email account password, which could help him reconstruct a key part of his past, but which someone wants to hide from him at all costs.

Giulia brings Andrea back to the ward for a patient who has asked to be exclusively examined by him and who does not know about his current condition. An error caused by his amnesia puts all the trainees under pressure. Meanwhile, Alba is forced to confront the resentment she feels towards her mother.

A special episode set ten years earlier. Andrea, an enthusiastic doctor who is still together with his family, has an opportunity to make a career jump for the first time. But it is a struggle to hold everything together: suddenly finding himself involved in a rivalry with his colleague Marco, he risks losing sight of who he really is.

Carolina, who is suffering from a mysterious illness, is admitted to the ward, triggering a series of conflicts between Andrea and Agnese that they will have to overcome for their daughter's sake. Meanwhile, a flashy influencer attracts the young trainees' attention and Alba cannot disguise her jealousy towards Riccardo.

In an attempt to return to his role as a father and to help Carolina recover from her illness, Andrea starts to pursue Agnese again. A bad headache creates problems for Gabriel while treating a patient. Elisa and Riccardo have to deal with an aspiring astronaut.

Andrea is confident that he has finally won over Agnese and, feeling romantic, he suggests that a wedding is organised in the ward for a patient in critical condition. Meanwhile, Gabriel makes an unexpected proposal that upsets the balance within the group of interns.

A patient sheds light on a secret about Lorenzo's private life that causes a stir throughout the ward. Meanwhile, Gabriel and Elisa must attempt to reconstruct the life of an elderly inpatient who appears not to remember anything about himself, but repeatedly utters a single word.

After finding the medical file on the patient who died because of a mistake, Andrea tries to reconstruct what happened before the shooting that wiped out his memory. Marco, who was responsible for this death, and Agnese are uncooperative. Alba and Riccardo struggle to rebuild their relationship and things also get complicated between Gabriel and Elisa.

A train accident turns the Internal Medicine ward into an improvised emergency room. All the doctors are required to do their best to deal with the emergency. One of the wounded is a girl who reopens an important chapter in Riccardo's past that the young man had considered closed forever.

The arrival of Elisa's older sister in the hospital, a likeable, charming actress, inexplicably makes the young trainee even more surly and bad-tempered. Andrea continues to delve into the years that amnesia has wiped out, while Agnese cannot mask her jealousy over the growing rapport between Giulia and Andrea.

Lorenzo has issues again with his ex-girlfriend Chiara, who is then hospitalized after overdosing. Marco and his wife feel increasingly threatened by the research that Andrea is carrying out on Satonal, the experimental drug that appears to have caused several deaths. Meanwhile, Gabriel has to explain to his community that he intends to settle in Italy.

Andrea finds himself in hot water when a former trainee accuses him of falsifying data from a pharmaceutical trial: unable to defend himself due to his amnesia, he seeks confirmation from people close to him. In the meantime, Lorenzo has to fight to get Chiara on the transplant list and Agnese has a sudden illness.

Agnese's condition rapidly deteriorates and Andrea receives the support of the whole ward in the attempt to discover what disease she is suffering from. However, the accusations levelled against him regarding his involvement in the falsification of data on pharmaceutical trials risk him having to leave the hospital for good.

February 2020. Doc is determined to keep his team together that is falling apart: Giulia will move to Genoa, Lorenzo will perhaps leave medicine, Gabriel is leaving for Ethiopia and even Elisa no longer seems interested in the department.

While Andrea seems intent on leaving everything, refusing to deal with the difficult case of the nurse Giacomo, a new internist, Damiano Cesconi, and a new infectious disease specialist, Cecilia Tedeschi, arrives in the hospital, but above all a new primary, who seems ready to dismantle the department from the inside.

In this special episode, while the investigation conducted by Caruso comes to life and the secrets of the pandemic begin to emerge, Andrea faces a difficult choice: to get back the primary he must take tests, but if he fails, he will never be able to be a doctor again.

Dealing with the case of a young tennis phenomenon, Andrea is forced to wonder if it is worth stopping being "Doc" to pursue the primary.

Engaged in following two cases at the same time to prove that he is up to the primary, Doc is in direct competition with the new primary and takes several risks.

While a small war breaks out between Doc and the surgeon Valenti because of Carolina, Doc must face the case of a boy with very present parents and is forced to question himself as a father.

While Caruso's tests have the increasingly clear intent to put Doc in difficulty, Cecilia also begins to discover the secret of the team.

All the secrets come to light in this special episode, a tribute to the medical heroes of the pandemic.

To treat an imprisoned mother, accused of trying to kill her daughter, Doc must fight against the prejudices of the entire hospital, just as he himself is being targeted by the investigation.

While our doctors are forced to take care of a patient, the rift between Doc and Carolina widens more and more, and Andrea must deal with himself.

Agnese is surprised to find Manuel's mother hospitalized, the child she has in foster care with Davide, and with whom things do not seem to go too well. Agnese will have to question everything she thinks she knows, just when Andrea seems to want to be closer to her than ever.

It's the day of the primary simulation for Doc: Andrea for a day returns to wear the gown, but a sudden computer blackout of the hospital's systems forces him to a series of risky choices.

While the doctors are busy solving the delicate case of a deafblind boy, Cecilia makes Doc an unexpected offer, triggering the jealousy of Agnese and Giulia.

Giulia is forced into a showdown with her cumbersome mother when her partner is hospitalized in the grip of an inexplicable syndrome. Just when Doc seems to be returning to primary, Cecilia discovers something compromising about him.

When he is one step away from regaining the primary, Doc is forced to a painful confession in front of the whole department.

Locked in the ward in a forced quarantine, doctors are engaged in a fight against time to stop a multidrug-resistant bacterium that has infected them all.

Again with his white coat, Doc faces his first day as head physician. He has new responsibilities to manage without neglecting patients, despite pressure from the Administrative Director who threatens to close the department. Fortunately, Doc can count on his team, although Julia has not set aside the idea of leaving and Richard is challenged by the new residents.

The news of Doc's memory upsets the ward's balance: Agnese fears that recovering his memory will destabilize Andrea's new life, while Damiano is worried about the effect this might have on Giulia. Doc, on the other hand, is increasingly elated, although it is not easy to wedge the therapy prescribed for him by Enrico between the thousands of commitments as head physician.

Doc continues to dig into his memory and, now that he has finally met his "sail," he has a clear lead to follow. He has Giulia at his side who, in addition to Andrea's problems, must also think about her career. Meanwhile, a famous travel blogger is admitted to the ward and entrusted to Federico's care. But this encounter is likely to create more than a few problems.

The search for Doc's memory seems to have come to a dead end, but Andrea has found a new "sail": the upcoming choir competition in honor of Mattia. While he tries to convince Agnese to accompany him, in the ward Federico ends up under pressure, and Riccardo is faced with a case that sends him into crisis and pushes his relationship with Martina to the limit.

After a new memory, Andrea finds it hard to believe what his memory seems to be suggesting to him, and he asks Enrico to discontinue treatment. Even on the ward, the situation is far from quiet. In addition to Rita, a young girl who refuses chemotherapy, Andrea and his team have to deal with the case of a patient they know all too well.

Doc sees some of the certainties he had about his past collapsing and, to shed light on what happened, he also drags Giulia into his search, who is challenged by the idea that her relationship with Andrea was based on a lie. Angelo, a patient whose condition forces Martina to prove herself, has problems with his past, too.

The therapy sessions with Enrico seem to have side effects on Doc, who sees his ability to take care of patients called into question. Agnese seizes the opportunity to crush his research into the past, while Giulia is convinced that Andrea should not give up, despite his problems: in fact, his brother Fabio is admitted to the ward.

Doc finally knows how to track down the woman he is looking for, but he must first find the courage to do so. Meanwhile, Ric faces the case of an undisciplined personal trainer, while Damiano must deal with the hospitalization of a model, his brother Samuele's girlfriend. This case threatens to bring up old family grudges.

The fear of discovering the secret about his past is too strong for Doc. However, this denial of the truth drives him away from the ward, much to the surprise of Giulia, who has to take care of a patient who, just like Andrea, seems to be hiding something. Meanwhile, Enrico must deal with Barbara's assaults, which may be hiding more than just infatuation.

Doc enters a competition with an AI: if he does not want to be replaced by a machine, he must find the correct diagnosis for a patient before the computer. Martina, on the other hand, is given a case that forces her to come to terms with her conscience, while Agnese is confronted with a terrible decision to protect one of Andrea's secrets.

Agnese's words have created a rift with Andrea, who must also come to terms with being away from Giulia, who is in Rome for research. Meanwhile, Teresa must work wonders to find a place for Diana's daughter, admitted despite her mother's doubts. Elisabetta is also admitted to the ward after a few days of illness, maybe an indication of a more serious problem.

A violent earthquake sows panic at the Ambrosiano Hospital. Lin is afraid for her family; Ric decides on Laura's proposal; Federico has to perform a surgery for which he does not feel ready; Martina has an encounter that threatens to bring up her secret; Giulia, on the other hand, has to manage the ward because Doc is stuck in an elevator and has to save a pregnant patient.

The deadline to submit the research is approaching, but Giulia seems to have other things on her mind. Even Doc struggles to manage the myriad commitments: there's the meeting with the funders and then there's Carolina, who is in town for a few days. Everything takes a back seat, however, when Lin's sister is hospitalized. A case that will force the resident to come to terms with her father.

Giulia must make a decision about her personal life that will also affect her career. While Martina faces the most difficult exam of her life, Ric takes on a case that will force him to come to terms with Alba's ghost. Lin and Federico, on the other hand, get back to work on the database, but they risk bringing Doc closer to the truth that Agnese has been hiding from him.

Andrea is forced to come to terms with Agnese's illness, but unexpected news from America reawaken his hopes. At the hospital, however, the new head physician is challenged by a case that will force someone to make a terrible compromise. Meanwhile, Lorenzo is entrusted with a patient who has arrived from a nursing home and has been prescribed an overdose of medication.

In the ward, the moment of truth has arrived. As Federico faces his last day at Ambrosiano Hospital and Martina makes a decision that leaves the rest of the team stunned, Doc must come to terms with the truth Agnese has told him. He is convinced that it can't get any worse - until the man responsible for it all, his worst enemy, is admitted.