Season 0 of The First 48 premiered on May 11, 2011.

Season 1 of The First 48 premiered on June 3, 2004.

Season 2 of The First 48 premiered on January 6, 2005.

Season 3 of The First 48 premiered on October 5, 2005.

Season 4 of The First 48 premiered on June 14, 2006.

Season 5 of The First 48 premiered on January 18, 2007.

Season 6 of The First 48 premiered on July 11, 2007.

Season 7 of The First 48 premiered on January 9, 2008.

Season 8 of The First 48 premiered on January 1, 2009.

Season 9 of The First 48 premiered on June 16, 2009.

Season 10 of The First 48 premiered on January 14, 2010.

Season 11 of The First 48 premiered on September 30, 2010.

Season 12 of The First 48 premiered on December 8, 2011.

Season 13 of The First 48 premiered on March 6, 2013.

Season 14 of The First 48 premiered on June 19, 2014.

Season 15 of The First 48 premiered on November 5, 2015.

Season 16 of The First 48 premiered on December 1, 2016.

Season 17 of The First 48 premiered on October 19, 2017.

Season 18 of The First 48 premiered on January 10, 2019.

Season 19 of The First 48 premiered on December 31, 2019.

Season 20 of The First 48 premiered on October 20, 2021.

Season 21 of The First 48 premiered on November 3, 2022.

Season 22 of The First 48 premiered on September 21, 2023.