Season 1 of The Hot Zone premiered on May 27, 2019.

Heroic U.S. Army scientist Dr. Nancy Jaax, working with a secret military specialized team, puts her life on the line to head off an Ebola outbreak before it spread to the human population.

Season 2 of The Hot Zone premiered on November 28, 2021.

After the events on 9/11, a team of experts track down the killer and mailer of the anthrax letters.