Series Cast 54

1. 

   Lucia Micarelli

   Annie Talarico (36 Episodes), — (3 Episodes)

2. 

   Melissa Leo

   Toni Bernette (36 Episodes), — (1 Episode)

3. 

   Khandi Alexander

   LaDonna Batiste-Williams (36 Episodes)

4. 

   Rob Brown

   Delmond Lambreaux (36 Episodes)

5. 

   Kim Dickens

   Janette Desautel (36 Episodes)

6. 

   Michiel Huisman

   Sonny (36 Episodes)

7. 

   Clarke Peters

   Albert "Big Chief" Lambreaux (36 Episodes)

8. 

   Wendell Pierce

   Antoine Batiste (36 Episodes)

9. 

   Steve Zahn

   Davis McAlary (36 Episodes)

10. 

    India Ennenga

    Sofia Bernette (26 Episodes), — (8 Episodes)

11. 

    David Morse

    Terry Colson (26 Episodes), — (3 Episodes)

12. 

    Jon Seda

    Nelson Hidalgo (26 Episodes)

13. 

    John Goodman

    Creighton Bernette (10 Episodes), — (9 Episodes)

14. 

    Chris Coy

    L.P. Everett (15 Episodes)

15. 

    Elizabeth Ashley

    Aunt Mimi (14 Episodes)

16. 

    Cornell Williams

    Cornell Williams (10 Episodes)

17. 

    Ntare Guma Mbaho Mwine

    — (7 Episodes)

18. 

    Tarra Riggs

    Lula Prichett (7 Episodes)

19. 

    Kermit Ruffins

    — (4 Episodes)

20. 

    Marc John Jefferies

    — (3 Episodes)

21. 

    Elvis Costello

    Self (2 Episodes)

22. 

    Marco St. John

    — (2 Episodes)

23. 

    Julie Adams

    — (2 Episodes)

24. Coco Robicheaux

    — (2 Episodes)

25. 

    Tom McDermott

    — (2 Episodes)

26. 

    Troy Anthony Young

    — (2 Episodes)

27. Big Sam

    — (2 Episodes)

28. 

    Rio Hackford

    — (2 Episodes)

29. 

    James DuMont

    — (1 Episode)

30. 

    Jaqueline Fleming

    — (1 Episode)

31. 

    Tim Reid

    — (1 Episode)

32. Lloyd Price

    — (1 Episode)

33. Cassandra Wilson

    — (1 Episode)

34. Dr. John

    — (1 Episode)

35. Nick Gomez

    — (1 Episode)

36. Jon Cleary

    — (1 Episode)

37. Roy Blount Jr.

    — (1 Episode)

38. 

    Terence Blanchard

    — (1 Episode)

39. Deacon John Moore

    — (1 Episode)

40. 

    Irma Thomas

    — (1 Episode)

41. Lawrence P. Beron

    — (1 Episode)

42. 

    Gary Grubbs

    — (1 Episode)

43. Art Neville

    — (1 Episode)

44. 

    Talia Balsam

    — (1 Episode)

45. Dave Bartholomew

    — (1 Episode)

46. 

    Louis Herthum

    — (1 Episode)

47. 

    Don Yesso

    — (1 Episode)

48. 

    Ivan Neville

    — (1 Episode)

49. Bob French

    — (1 Episode)

50. 

    Lucinda Williams

    Self (1 Episode)

51. 

    Anthony Anderson

    Derek Watson (1 Episode)

52. Catherine Lasperches

    — (1 Episode)

53. Eric R. Moreland

    Father Marcus (1 Episode)

54. 

    Renell Gibbs

    — (1 Episode)

Series Crew 23